abstract：:The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...

journal_title：Brain research

authors： Piao LH,Fujita T,Yu T,Kumamoto E

更新日期：2017-02-15 00:00:00

abstract：:Recent studies have reported microglia that are activated in the central nervous system (CNS) in patients with temporal lobe epilepsy and animal models of epilepsy. However, limited data are available on the dynamic changes of the proportions of various phenotypes of microglia throughout epileptogenesis and whether IL...

journal_title：Brain research

authors： Li T,Zhai X,Jiang J,Song X,Han W,Ma J,Xie L,Cheng L,Chen H,Jiang L

更新日期：2017-02-15 00:00:00

abstract：:Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...

journal_title：Brain research

authors： Demchenko IT,Zhilyaev SY,Moskvin AN,Krivchenko AI,Piantadosi CA,Allen BW

更新日期：2017-02-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...

journal_title：Brain research

authors： Gao H,Han Z,Bai R,Huang S,Ge X,Chen F,Lei P

更新日期：2017-02-15 00:00:00

abstract：:Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...

journal_title：Brain research

authors： Mattis VB,Svendsen CN

更新日期：2017-02-01 00:00:00

abstract：:Maternal care is crucial for offspring development and licking/grooming patterns can be induced by sensorial, neuroendocrine, and metabolic variations in the CNS. Important brain functions, such as learning and memory, can be influenced by oxidative stress, which can also modulate pathophysiological processes (e.g., d...

journal_title：Brain research

authors： De Moura AC,Brito VB,Porawski M,Saffi J,Giovenardi M

更新日期：2017-01-15 00:00:00

abstract：:Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...

journal_title：Brain research

authors： Zhang ZN,Zhang JS,Xiang J,Yu ZH,Zhang W,Cai M,Li XT,Wu T,Li WW,Cai DF

更新日期：2017-01-15 00:00:00

abstract：:Physical exercise can induce brain plasticity and reduce the cognitive decline observed in type 1 diabetes mellitus (T1DM). We investigated the effects of physical exercise to prevent or reverse spatial memory deficits produced by diabetes and some biochemical and immunohistochemical changes in hippocampal astrocytes ...

journal_title：Brain research

authors： de Senna PN,Bagatini PB,Galland F,Bobermin L,do Nascimento PS,Nardin P,Tramontina AC,Gonçalves CA,Achaval M,Xavier LL

更新日期：2017-01-15 00:00:00

abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...

journal_title：Brain research

authors： Gerth AI,Alhadeff AL,Grill HJ,Roitman MF

更新日期：2017-01-15 00:00:00

abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...

journal_title：Brain research

authors： Simon NW,Moghaddam B

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...

journal_title：Brain research

authors： Chai D,Jiang H,Li Q

更新日期：2016-12-15 00:00:00

abstract：:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...

journal_title：Brain research

authors： Arredondo C,González M,Andrés ME,Gysling K

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Our asphyxia cardiac arrest (ACA) rat model is well established. The original model was designed in the 1990th using halothane and nitrous oxide for pre-insult anesthesia. Because of its hepato-toxicity and its potential to induce severe liver failures, halothane is no longer used in clinical anesthesia for s...

journal_title：Brain research

authors： Esser T,Keilhoff G,Ebmeyer U

更新日期：2016-12-01 00:00:00

abstract：:The delay associated with cerebral processing time implies a lack of real-time representation of changes in the observed environment. To bridge this gap for motor actions in a dynamical environment, the brain uses predictions of the most plausible future reality based on previously provided information. To optimise th...

journal_title：Brain research

authors： Beudel M,Leenders KL,de Jong BM

更新日期：2016-12-01 00:00:00

abstract：:Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...

journal_title：Brain research

authors： Pogačnik L,Pirc K,Palmela I,Skrt M,Kim KS,Brites D,Brito MA,Ulrih NP,Silva RF

更新日期：2016-11-15 00:00:00

abstract：:We utilized proton magnetic resonance spectroscopy to evaluate the metabolic profile of the hippocampus and anterior cingulate cortex of the developing rat brain from postnatal days 14-70. Measured metabolite concentrations were modeled using linear, exponential, or logarithmic functions and the time point at which th...

journal_title：Brain research

authors： Ramu J,Konak T,Liachenko S

更新日期：2016-11-15 00:00:00

abstract：:This EEG study (N=33) examined event-related potentials associated with conflict between activated responses in the Stroop task, in order to examine the conflict monitoring theory of cognitive control, which predicts the strength of exerted control to be proportional to the detected level of conflict. However, existin...

journal_title：Brain research

authors： Chuderski A,Senderecka M,Kałamała P,Kroczek B,Ociepka M

更新日期：2016-11-01 00:00:00

abstract：:Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...

journal_title：Brain research

authors： Jumnongprakhon P,Govitrapong P,Tocharus C,Tocharus J

更新日期：2016-11-01 00:00:00

abstract：:Our recent researches have identified increased expression of miR-21-5p in rats brain following traumatic brain injury (TBI), which protected against blood-brain barrier (BBB) damage. To further study the mechanism underlying the role of miR-21-5p on alleviating BBB damage after TBI, we performed the scratch injury mo...

journal_title：Brain research

authors： Ge X,Huang S,Gao H,Han Z,Chen F,Zhang S,Wang Z,Kang C,Jiang R,Yue S,Lei P,Zhang J

更新日期：2016-11-01 00:00:00

abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...

journal_title：Brain research

authors： Alcayaga J,Oyarce MP,Del Rio R

更新日期：2016-10-15 00:00:00

abstract：:Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...

journal_title：Brain research

authors： Lim Y,Cho H,Kim EK

更新日期：2016-10-15 00:00:00

abstract：:The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...

journal_title：Brain research

authors： Altinbas B,Guvenc G,Erkan LG,Ilhan T,Niaz N,Yalcin M

更新日期：2016-10-15 00:00:00

abstract：:During functional spinal neural network activity motoneurons receive massive synaptic excitation and inhibition, and their membrane conductance increases considerably - they are switched to a high-conductance state. High-conductance states can substantially alter response properties of motoneurons. In the present stud...

journal_title：Brain research

authors： Grigonis R,Guzulaitis R,Buisas R,Alaburda A

更新日期：2016-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...

journal_title：Brain research

authors： Zhou X,Su S,Li S,Pang X,Chen C,Li J,Liu J

更新日期：2016-10-01 00:00:00

abstract：:Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...

journal_title：Brain research

authors： Valenzuela V,Oñate M,Hetz C,Court FA

更新日期：2016-10-01 00:00:00

abstract：:Poor sleep and insomnia have been recognized to be strongly correlated with the development of depression. The exploration of the basic mechanism of sleep disturbance could provide the basis for improved understanding and treatment of insomnia and prevention of depression. In this study, 31 subjects with insomnia symp...

journal_title：Brain research

authors： Liu CH,Liu CZ,Zhang J,Yuan Z,Tang LR,Tie CL,Fan J,Liu QQ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...

journal_title：Brain research

authors： Wang D,Li YH,Fu J,Wang H

更新日期：2016-10-01 00:00:00

abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...

journal_title：Brain research

authors： Green KM,Linsalata AE,Todd PK

更新日期：2016-09-15 00:00:00

abstract：:The immunolocalization of the 14-3-3 eta isoform in the anterior horn cells (AHCs) of patients with sporadic amyotrophic lateral sclerosis (ALS) and controls was examined. Compared with the immunolocalization of other 14-3-3 isoforms, the immunolocalization of the 14-3-3 eta isoform was either synaptic at the peripher...

journal_title：Brain research

authors： Umahara T,Uchihara T,Shibata N,Nakamura A,Hanyu H

更新日期：2016-09-01 00:00:00

abstract：:With the increasing worldwide incidence of Alzheimer's disease (AD), there is a critical need for the discovery of more effective diagnostic methods. However, development of diagnostic tools in AD has been hindered by obstacles such as the absence of exact biomarkers. Apoptosis caused by amyloid-β (Aβ) plays an import...

journal_title：Brain research

authors： Lee JK,Wang K,Park MH,Kim N,Lee JY,Jin HK,Kim IS,Lee BH,Bae JS

更新日期：2016-09-01 00:00:00

abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...

journal_title：Brain research

authors： Hood RL,Liguore WA,Moore C,Pflibsen L,Meshul CK

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate whether β-amyloid (Aβ) was able to enhance neurocan expression in a Sox9 dependent manner in astrocytes. METHODS AND MATERIALS:Astrocytes were incubated with Aβ at different concentrations, the expression of Sox9 and neurocan was detected by Western blot assay. Meanwhile, the ...

journal_title：Brain research

authors： Yan H,Zhu X,Xie J,Zhao Y,Liu X

更新日期：2016-09-01 00:00:00

abstract：:The ketogenic diet (KD) controls seizure and improves cognition in patients with drug refractory epilepsy. However, few experimental models have shown this neuroprotective effect on cognition. In this study, we investigated the cognitive protective effects of KD in pentylenetetrazol (PTZ)-kindled rats. We used two rel...

journal_title：Brain research

authors： Jiang Y,Lu Y,Jia M,Wang X,Zhang Z,Hou Q,Wang B

更新日期：2016-09-01 00:00:00

abstract：:Perinatal asphyxia to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term born infants with hypoxic-ischemic encephalopathy, saving one in seven to eight infants from developing severe neurological deficits. Therefore, addi...

journal_title：Brain research

authors： Strasser K,Lueckemann L,Kluever V,Thavaneetharajah S,Hoeber D,Bendix I,Fandrey J,Bertsche A,Felderhoff-Mueser U

更新日期：2016-09-01 00:00:00

abstract：:Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. This suggests that glucocorticoid availability in the ventral hippocampus during stress may be reduced during am...

journal_title：Brain research

authors： Bray B,Scholl JL,Tu W,Watt MJ,Renner KJ,Forster GL

更新日期：2016-08-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) modulates neurogenesis, neuronal function, neuronal survival and metabolism, enhancing mitochondrial oxidative capacity. Glucose deprivation and hypometabolism have been implicated in the mechanisms that mediate neuronal damage in neurological disorders, and some studies have shown that t...

journal_title：Brain research

authors： Vieira-Marques C,Arbo BD,Ruiz-Palmero I,Ortiz-Rodriguez A,Ghorbanpoor S,Kucharski LC,Arevalo MA,Garcia-Segura LM,Ribeiro MF

更新日期：2016-08-01 00:00:00

abstract：:Sustained neuroinflammation contributes to the pathogenesis of postoperative cognitive dysfunction. Dexmedetomidine, a selective α-2 adrenergic receptor agonist, exhibits a protective role in the brain. This study investigated whether dexmedetomidine pretreatment attenuates neuroinflammation induced by tibial fracture...

journal_title：Brain research

authors： Zhu YJ,Peng K,Meng XW,Ji FH

更新日期：2016-08-01 00:00:00

abstract：:This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from...

journal_title：Brain research

authors： Manard M,Bahri MA,Salmon E,Collette F

更新日期：2016-07-01 00:00:00

abstract：:Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...

journal_title：Brain research

authors： Ko M,Hattori T,Abdullah M,Gong JS,Yamane T,Michikawa M

更新日期：2016-07-01 00:00:00

abstract：:Experimental traumatic brain injury (TBI) is known to produce an acute increase in cerebral glucose utilization, followed rapidly by a generalized cerebral metabolic depression. The current studies determined effects of single or multiple treatments with sodium pyruvate (SP; 1000mg/kg, i.p.) or ethyl pyruvate (EP; 40m...

journal_title：Brain research

authors： Moro N,Ghavim SS,Harris NG,Hovda DA,Sutton RL

更新日期：2016-07-01 00:00:00